engleski

The genetics of psoriasis -what's new?

Psoriasis is a multifactorial, heterogenetically inherited disease. On the basis of epidemiological study and HLA association, a concept of two distinct disease patterns of psoriasis vulgaris has been proposed. Type I psoriasis has early appearance, familial inheritance, and strong correlation with Cw6, B 13, B57 and DR7 antigens. Type II psoriasis has late onset, weak correlation with HLA antigens and rare familial occurence. HLA Cw6 confers the largest and the most consistently demonstrated risk factors. Today, it is also clear that a major candidate gene(s) for psoriasis is located within MHC complex and that it is linked with the HLA-Cw6 locus. Understanding of the genetic basis of psoriasis will represent a major advance in our knowledge of the disease and will reveal novel disease-specific biologic pathways. This information will be used to develop more specific diagnostic and prognostic tools, and will also lead to the development of individualized treatment plans.

psoriasis vulgaris; genetics

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