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Pregled bibliografske jedinice broj: 266638

The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself


Aleksić, Joško; Čulo, Melanie-Ivana; Poljak, Ljiljana; Matić, Tomas; Čulo, Filip
The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself // Proceedings of the 6th International Cytokine Conference / Schwarzmeier, Josef D (ur.).
Bologna: Medimond, 2007. str. 1-7 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)


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Naslov
The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself

Autori
Aleksić, Joško ; Čulo, Melanie-Ivana ; Poljak, Ljiljana ; Matić, Tomas ; Čulo, Filip

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of the 6th International Cytokine Conference / Schwarzmeier, Josef D - Bologna : Medimond, 2007, 1-7

Skup
International Cytokine Conference (6 ; 2006)

Mjesto i datum
Beč, Austrija, 27.-31.08.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
interleukin-1beta; IL-1alpha; IL-1Ra; acetaminophen; hepatoprotection
(interleukin-1beta; IL-1alpha IL-1Ra; acetaminophen; hepatoprotection)

Sažetak
The effect of mouse recombinant IL-1beta and its antagonists (IL-1Ra and rabbit polyclonal antibodies to mouse IL-1beta) on survival of animals and concentration of serum aminotransferases (AST and ALT) was investigated in mice intoxicated with acetaminophen (APAP). IL-1beta (1000 IU/mouse) or IL-1beta antibody (0.5 mL/mouse) were given i.p. 3 hours before APAP and IL-Ra (2.5 mg/mouse) half hour before APAP, which was administered by gastric lavage. IL-1beta significantly increased the survival mice and decreased plasma level of AST and ALT (p<0.05). Essentially, opposite effect had anti-IL-1beta antibodies and IL-1Ra. RT-PCR analysis has revealed that administration of APAP induces the expression of both IL-1beta and IL-1alpha in liver samples already 1 hour after its administration, indicating that the synthesis of these cytokines is part of host defense reaction to toxic effect of APAP. The expression of cytokines at induced by APAP administration could be blocked by pretreatment of mice with aspirin.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

Napomena
Očekuje se da će se edicija, u kojoj je rad objavljen, biti indeksirana u CC.



POVEZANOST RADA


Projekti:
108-0000000-0328 - Uloga proupalnih citokina i prostaglandina u akutnom oštećenju jetre

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Ljiljana Poljak (autor)

Avatar Url Filip Čulo (autor)

Avatar Url Melanie Ivana Čulo (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Aleksić, Joško; Čulo, Melanie-Ivana; Poljak, Ljiljana; Matić, Tomas; Čulo, Filip
The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself // Proceedings of the 6th International Cytokine Conference / Schwarzmeier, Josef D (ur.).
Bologna: Medimond, 2007. str. 1-7 (poster, međunarodna recenzija, cjeloviti rad (in extenso), znanstveni)
Aleksić, J., Čulo, M., Poljak, L., Matić, T. & Čulo, F. (2007) The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself. U: Schwarzmeier, J. (ur.)Proceedings of the 6th International Cytokine Conference.
@article{article, editor = {Schwarzmeier, J.}, year = {2007}, pages = {1-7}, keywords = {interleukin-1beta, IL-1alpha, IL-1Ra, acetaminophen, hepatoprotection}, title = {The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself}, keyword = {interleukin-1beta, IL-1alpha, IL-1Ra, acetaminophen, hepatoprotection}, publisher = {Medimond}, publisherplace = {Be\v{c}, Austrija} }
@article{article, editor = {Schwarzmeier, J.}, year = {2007}, pages = {1-7}, keywords = {interleukin-1beta, IL-1alpha IL-1Ra, acetaminophen, hepatoprotection}, title = {The protective effect of interleukin 1apha and IL-1beta on the acetaminophen induced liver toxicity relies on the early induction of their endogenous expression by acetaminophen itself}, keyword = {interleukin-1beta, IL-1alpha IL-1Ra, acetaminophen, hepatoprotection}, publisher = {Medimond}, publisherplace = {Be\v{c}, Austrija} }




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