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Pregled bibliografske jedinice broj: 266525

TNF-alpha promoter SNPs in gastroenteropancreatic neuroendocrine tumors (GEP-NET)

Berković, Maja; Čačev, Tamara; Zjačić-Rotkvić, Vanja; Kapitanović, Sanja
TNF-alpha promoter SNPs in gastroenteropancreatic neuroendocrine tumors (GEP-NET) // Neuroendocrinology, 84 (2006), 5; 346-352 doi:10.1159/000097988 (međunarodna recenzija, članak, znanstveni)

TNF-alpha promoter SNPs in gastroenteropancreatic neuroendocrine tumors (GEP-NET)

Berković, Maja ; Čačev, Tamara ; Zjačić-Rotkvić, Vanja ; Kapitanović, Sanja

Neuroendocrinology (0028-3835) 84 (2006), 5; 346-352

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Neuroendocrine tumors; tumor necrosis factor alpha; polymorphism

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) secrete biogenic amines, hormones and growth factors, among which tumor necrosis factor alpha (TNF-alpha). As the expression of TNF-alpha is mostly regulated at the transcriptional level, its promoter polymorphisms have been intensively studied as a potential determinant of TNF-alpha production and cancer susceptibility. We have analyzed for the first time the potential association between -238, -308, -857 and -1031 TNF-alpha promoter polymorphisms and GEP-NETs. The study included 65 individuals diagnosed with GEP-NET and 154 healthy age and sex matched controls. Although most of the patients had solitary GEP-NETs, six were diagnosed with GEP-NET as a part of multiple endocrine neoplasia type 1 (MEN-1) and one as a part of neurofibromatosis type 1 (NF-1). The C allele at the -1031 position was more frequent in GEP-NET patients (p<0.0005) suggesting its possible role in GEP-NET development. The significant difference between forgut and midgut GEP-NET patients was observed in the -308 high expression genotypes and -308A allele (high expression) which tend to occur more frequently in the forgut GEP-NETs (p=0.0392 and p=0.0350 respectively). When functional and non-functional PETs were compared there were no significant differences in the researched TNF-alpha SNPs. The results suggest the putative role of TNF-alpha -1031 polymorphism in the development of GEP-NET.

Izvorni jezik

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti


Projekt / tema

Institut "Ruđer Bošković", Zagreb

Časopis indeksira:

  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus