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izvor podataka: crosbi

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants (CROSBI ID 126723)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Kostović, Ivica ; Judaš, Miloš Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants // Developmental medicine and child neurology, 48 (2006), 5; 388-393-x

Podaci o odgovornosti

Kostović, Ivica ; Judaš, Miloš

engleski

Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants

The aim of this paper is to evaluate correlative magnetic resonance imaging (MRI) and histological parameters of development of cortical afferents during pathfinding and target selection in transient fetal cerebral laminas in human fetuses and preterm infants. The transient fetal subplate zone, situated between the fetal white matter (i.e. intermediate zone) and the cortical plate, is the crucial laminar compartment for development of thalamocortical and corticocortical afferents. The prolonged coexistence of transient (endogenously active) and permanent (sensory-driven) circuitry within the transient fetal zones is a salient feature of the fetal and preterm cortex ; this transient circuitry is the substrate of cerebral functions in preterm infants. Another transient aspect of organization of developing fibre pathways is the abundance of extracellular matrix and guidance molecules in periventricular crossroads of projection and corticocortical pathways. Both the subplate zone and periventricular crossroads are visible on MRI in vivo and in vitro. Hypoxic-ischaemic lesions of periventricular crossroads are the substrate for motor, sensory, and cognitive deficits after focal periventricular leukomalacia (PVL). Lesions of distal portions of the white matter and the subplate zone are the substrate for diffuse PVL. The neuronal elements in transient fetal zones form a developmental potential for plasticity after perinatal cerebral lesions.

white-matter injury; periventricular leukomalacia; cognitive-development; somatosensory cortex; laminar organization; cortical development; premature-infants; subplate neurons; rhesus-monkey; brain-injury

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Podaci o izdanju

48 (5)

2006.

388-393-x

objavljeno

0012-1622

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost