engleski

Different central action of streptozotocin and alloxan on cognition

Strepotozotocin and alloxan are selective toxic for insulin producing/secreting cells, producing diabetes mellitus after peripheral, but not after central administration., with similar alterations of brain monoamine transmission found following the both administrations. Recently, cognitive deficits have been found in streptozotocin-intracerebroventricularly (STZ-icv) treated rats, while cognition in alloxan-icv treated rats has not been investigated. By means of Morris Water Maze Swimming Test, we have compared memory and learning functions in STZ- and alloxan-icv treated rats, 3 months after the icv drug treatment. Contrary to the statistically significant decrement of these functions in STZ-icv rats, alloxan-icv treated rats had no significant cognitive deficits in comparison to the respective controls. Regardless their similar peripheral metabolic effects, and some similar central neurochemical effects, STZ- and alloxan-icv treatment demonstrate different influence on cognition, the latter being deprived of any effect.

streptozotocin; alloxan; intracerebroventricular; cognition

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