Comparative study of PDD fluorescent excitation and image processing methods (CROSBI ID 521197)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kopriva, Ivica ; Zorc, Hrvoje ; Peršin Antun ; Lipozenčić, Jasna ; Pašić, Aida ; Kostović, Krešimir, Lončarić, Martin
engleski
Comparative study of PDD fluorescent excitation and image processing methods
Photodynamic diagnostics of skin tumors is based on the visualization of fluorophores, which accumulate in tumor tissue, by use of fluorescence imaging. Of particular importance is application of  -5-aminolaevulinic acid (ALA) that stimulates formation of protoporphyrin IX (Pp IX) through the process of biosynthesis. Higher concentration of Pp IX in tumor tissue, compared to surrounding healthy skin, is the basis for PDD. The study has been done on a patient suffering from Basal Cell Carcinoma (BCC) treated with ALA. Our contribution in this communication is twofold. First, we have compared performance of four fluorescence excitations in term of the quality of BCC localization. We have used the following excitation sources: 405 nm lamp (MEDILED-5), the Wood’ s lamp, the MEDILED-5 and Wood’ s lamp together and the filtered photo flash lamp. We have demonstrated that fluorescent image obtained using excitation with MEDILED-5 lamp is the most consistent in term of the quality of BCC localization. Second, we have compared three methods used for the processing of fluorescent BCC images in order to obtain the BCC spatial maps. The following three image processing methods have been applied: the ratio imaging, optimal threshold and independent component analysis (ICA). The ratio image is obtained by calculating ratio between red and green component for every pixel. The optimal threshold image is obtained by classifying as a BCC everything that is above 1.4Ia, where Ia represents average intensity of the region with healthy skin. We have demonstrated that BCC spatial map produced by ICA is most consistent in term of the quality of BCC localization.
independent component analysis; picture processing; photodynamic diagnosis
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Podaci o prilogu
2006.
objavljeno
Podaci o matičnoj publikaciji
6th International Symposium on Photodynamic Diagnosis and Therapy in Clinical Practice
H. Kostron, G. Jori
Podaci o skupu
6th International Symposium on Photodynamic Diagnosis and Therapy in Clinical Practice
predavanje
10.10.2006-14.10.2006
Bressanone, Italija