engleski

A study of bone histomorphometry in advanced osteoarthritis of the femoral head in humans.

The development of bone tissue changes in osteoarthritis indicates differences in local bone remodeling. The advanced stage of hip osteoarthritis may be surgicaly treated by hip replacement. The aim of this study was assessment of bone turnover by histomorphometric analysis of the three areas from the osteoarthritic femoral head removed during hip replacement: preserved articular cartilage, exposed subchondral bone and osteophyte. This study comprised 23 patients (10 males, 13 females) aged 55-65 years undergoing hip replacement surgery. Histomorphometry was performed by semi-automated method using Vamstec (Zagreb) software under magnification x100. Measurements were performed and parameters calculated according to the recommendations of the American society for bone and mineral research: bone volume (BV/TV, %), osteoblast surface (Ob.S/BS, %), osteoid thickness (O.Th, um), osteoclast surface (Oc.S/BS, %), trabecular thickness (TbTh, um), trabecular separation (TbS, um), trabecular number (TbN, n/mm2) and number of osteoclasts (NOC, n/mm). Bone structure as assessed by histomorphometry differs in the femoral head osteoarthritis depending on local degenerative processes. Better bone tissue traits, mostly structural indices, were related to less advanced osteoarthritic changes i.e. located in areas of preserved articular cartilage, and reduced bone characteristics were found in the osteophyte area.

bone; histomorphometry

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