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Pregled bibliografske jedinice broj: 265220

Variations of bone histomorphometry in advanced osteoarthritis of the femoral head.


Kušec, Vesna; Starešinić, Mario; Krpan, Dalibor; Šebečić, Božidar
Variations of bone histomorphometry in advanced osteoarthritis of the femoral head. // Calciffied Tissue International, 78 (2006), suplement 1. (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)


CROSBI ID: 265220 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Variations of bone histomorphometry in advanced osteoarthritis of the femoral head.

Autori
Kušec, Vesna ; Starešinić, Mario ; Krpan, Dalibor ; Šebečić, Božidar

Izvornik
Calciffied Tissue International (0171-967x) 78 (2006), Suplement 1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
bone

Sažetak
Osteoarthritis is characterised by deterioration of articular cartilage and formation of new bone at the joint surfaces and margins. The development of bone tissue changes in osteoarthritis indicates differences in local bone remodeling. The aim of this study was histomorphometric analysis of three areas of the osteoarthritic femoral head: preserved articular cartilage, exposed subchondral bone and osteophyte. This study comprised 23 patients (10 males, 13 females) aged 55-65 years undergoing hip replacement. Bone specimens (cca 1 cm3) were removed from the femoral head, embedded in resin and sections stained with toluidine blue for static histomorphometric parameters. Higher values in men than in women were found for bone volume (BV/TV ; p<0.04) and osteoclast number (NOC ; p<0.002) in the preserved cartilage area, and also for osteoblast surface (ObS/BS ; p<0.006) in the osteophyte area. Difference in histomorphometric parameters between sampling locations indicated better bone structure in areas of preserved cartilage in comparison to osteophytic bone: higher BV/TV (p<0.001), TbTh (p<0.02), TbN (p<0.008), ObS (p<0.02) and less TbS (p<0.0005). Bone structure as assessed by histomorphometry differs in femoral head osteoarthritis depending on local degenerative processes. Better bone tissue traits, mostly structural indices, were related to less advanced osteoarthritic changes i.e. located in areas of preserved articular cartilage, and reduced bone characteristics were found in the osteophyte area. Sex differences were observed for bone volumen and some cellular indices, but not in all examined areas. In conclusion, variations of bone structural and cellular indices of advanced osteoarthritis of the femoral head are related to differences of bone degenerative processes in this disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0214200

Ustanove:
Klinički bolnički centar Zagreb


Citiraj ovu publikaciju:

Kušec, Vesna; Starešinić, Mario; Krpan, Dalibor; Šebečić, Božidar
Variations of bone histomorphometry in advanced osteoarthritis of the femoral head. // Calciffied Tissue International, 78 (2006), suplement 1. (podatak o recenziji nije dostupan, kongresno priopcenje, znanstveni)
Kušec, V., Starešinić, M., Krpan, D. & Šebečić, B. (2006) Variations of bone histomorphometry in advanced osteoarthritis of the femoral head.. Calciffied Tissue International, 78 (suplement 1).
@article{article, author = {Ku\v{s}ec, Vesna and Stare\v{s}ini\'{c}, Mario and Krpan, Dalibor and \v{S}ebe\v{c}i\'{c}, Bo\v{z}idar}, year = {2006}, pages = {s92}, keywords = {bone}, journal = {Calciffied Tissue International}, volume = {78}, number = {suplement 1}, issn = {0171-967x}, title = {Variations of bone histomorphometry in advanced osteoarthritis of the femoral head.}, keyword = {bone} }
@article{article, author = {Ku\v{s}ec, Vesna and Stare\v{s}ini\'{c}, Mario and Krpan, Dalibor and \v{S}ebe\v{c}i\'{c}, Bo\v{z}idar}, year = {2006}, pages = {s92}, keywords = {bone}, journal = {Calciffied Tissue International}, volume = {78}, number = {suplement 1}, issn = {0171-967x}, title = {Variations of bone histomorphometry in advanced osteoarthritis of the femoral head.}, keyword = {bone} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI





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