engleski

Variations of bone histomorphometry in advanced osteoarthritis of the femoral head.

Osteoarthritis is characterised by deterioration of articular cartilage and formation of new bone at the joint surfaces and margins. The development of bone tissue changes in osteoarthritis indicates differences in local bone remodeling. The aim of this study was histomorphometric analysis of three areas of the osteoarthritic femoral head: preserved articular cartilage, exposed subchondral bone and osteophyte. This study comprised 23 patients (10 males, 13 females) aged 55-65 years undergoing hip replacement. Bone specimens (cca 1 cm3) were removed from the femoral head, embedded in resin and sections stained with toluidine blue for static histomorphometric parameters. Higher values in men than in women were found for bone volume (BV/TV ; p<0.04) and osteoclast number (NOC ; p<0.002) in the preserved cartilage area, and also for osteoblast surface (ObS/BS ; p<0.006) in the osteophyte area. Difference in histomorphometric parameters between sampling locations indicated better bone structure in areas of preserved cartilage in comparison to osteophytic bone: higher BV/TV (p<0.001), TbTh (p<0.02), TbN (p<0.008), ObS (p<0.02) and less TbS (p<0.0005). Bone structure as assessed by histomorphometry differs in femoral head osteoarthritis depending on local degenerative processes. Better bone tissue traits, mostly structural indices, were related to less advanced osteoarthritic changes i.e. located in areas of preserved articular cartilage, and reduced bone characteristics were found in the osteophyte area. Sex differences were observed for bone volumen and some cellular indices, but not in all examined areas. In conclusion, variations of bone structural and cellular indices of advanced osteoarthritis of the femoral head are related to differences of bone degenerative processes in this disease.

bone

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