engleski

Topical photodynamic therapy in the treatment of malignant epidermal precancerous and cancerous lesions

Photodynamic therapy (PDT) mediated by 5-aminolevulinic acid (ALA) has been introduced as a new anticancer therapeutic modalities. In January 2004, we have started topical PDT in the treatment selected group of patients with epidermal precancerous and cancerous lesions. Lesions were treated by topical application of 20% 5-ALA dissolved a proprietary oil-in- water emulsion. The ALA containing emulsion was applied under occlusive dressing 5-6 hours before illumination with non-coherent red light (630-700 nm, light dose 100-150 J/cm2). Prior to therapy diagnostics has been done using MEDILED-5 device. In our study 50 patients were included (twenty four men and twenty six women). Twenty patients had superficial basal cell carcinoma, eleven patients had other types of basal cell carcinoma, eleven had Bowen's disease and eight patients had other precancerous and cancerous lesions. Nine patients had recurrences after surgical excision and/or radiotherapy. In most patients complete or partial regression was achieved after one to three treatments. PDT is an alternative modality to surgical excision or superficial radiotherapy. This is also a good option for the treatment of recurrences after surgical treatment and superficial radiotherapy.

photodynamic therapy; photodynamic diagnosis

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