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Pregled bibliografske jedinice broj: 264682

Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients


Reiner, Željko; Tedeschi-Reiner, Eugenia; Romić, Željko
Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients // Clinical Drug Investigations, 25 (2005), 11; 701-707 (međunarodna recenzija, članak, znanstveni)


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Naslov
Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients

Autori
Reiner, Željko ; Tedeschi-Reiner, Eugenia ; Romić, Željko

Izvornik
Clinical Drug Investigations (1173-2563) 25 (2005), 11; 701-707

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
policosanol; lipoproteins; homocysteine; CRP

Sažetak
Background: Policosanol is an agent that includes mixtures of aliphatic primary alcohols extracted primarily from sugar-cane wax. This mixture has been shown to lower total and low-density lipoprotein (LDL) cholesterol in animal models, healthy volunteers and hypercholesterolaemic patients. Patients and methods: This study investigated the efficacy and tolerability of rice policosanol (Oryza sp.) 10 mg/day in 70 hypercholesterolaemic patients of both sexes aged 20-78 years in a randomised, double-blind, crossover, placebo-controlled, single-centre trial. After an 8-week run-in period during which patients were placed on therapeutic lifestyle changes, in particular a cholesterol-lowering diet, they were randomly assigned to receive rice policosanol 10 mg tablets or placebo tablets once daily with the evening meal for 8 weeks. During the next 8 weeks those patients who received policosanol during the first 8 weeks received placebo, and those who received placebo during the first 8 weeks, received policosanol. Total, LDL, high-density lipoprotein (HDL), HDL2 and HDL3 cholesterol, triglycerides, oxidised LDL (ox-LDL), apoproteins (Apos) AI and B, lipoprotein (a) [Lp(a)], fibrinogen, homocysteine and C-reactive protein (CRP) levels were measured. Results: Rice policosanol significantly reduced plasma total cholesterol from 7.37 +/- 1.42 mmol/L to 6.99 +/- 1.33 mmol/L (p = 0.007) and increased Apo AI from 1.49 +/- 0.39 mmol/L to 1.58 +/- 0.38 mmol/L (p = 0.037) but did not change plasma triglycerides, HDL, HDL2, HDL3 and LDL cholesterol, ox-LDL, Lp(a), Apo B, fibrinogen, homocysteine or CRP levels. Conclusion: Rice policosanol 10 mg/day moderately decreased plasma total cholesterol and increased Apo AI. Rice policosanol was also well tolerated, with no drug-related effects on safety parameters such as serum aminotransferases and creatine phosphokinase detected or found on physical examination.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
0108230

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Željko Reiner (autor)

Avatar Url Željko Romić (autor)

Citiraj ovu publikaciju

Reiner, Željko; Tedeschi-Reiner, Eugenia; Romić, Željko
Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients // Clinical Drug Investigations, 25 (2005), 11; 701-707 (međunarodna recenzija, članak, znanstveni)
Reiner, Ž., Tedeschi-Reiner, E. & Romić, Ž. (2005) Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients. Clinical Drug Investigations, 25 (11), 701-707.
@article{article, year = {2005}, pages = {701-707}, keywords = {policosanol, lipoproteins, homocysteine, CRP}, journal = {Clinical Drug Investigations}, volume = {25}, number = {11}, issn = {1173-2563}, title = {Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients}, keyword = {policosanol, lipoproteins, homocysteine, CRP} }
@article{article, year = {2005}, pages = {701-707}, keywords = {policosanol, lipoproteins, homocysteine, CRP}, journal = {Clinical Drug Investigations}, volume = {25}, number = {11}, issn = {1173-2563}, title = {Effects of Rice Policosanol on Serum Lipoproteins, Homocysteine, Fibrinogen and C-Reactive Protein in Hypercholesterolaemic Patients}, keyword = {policosanol, lipoproteins, homocysteine, CRP} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus





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