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TP53, Bcl-2 and growth hormone receptor expression in cutaneous squamous cell carcinoma (CROSBI ID 126393)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Stanimirović, Andrija ; Čupić, Hrvoje ; Bošnjak, Berislav ; Tomas, Davor ; Krušlin, Božo ; Belicza, Mladen TP53, Bcl-2 and growth hormone receptor expression in cutaneous squamous cell carcinoma // Acta Dermatovenerologica Croatica, 13 (2005), 4; 201-5-x

Podaci o odgovornosti

Stanimirović, Andrija ; Čupić, Hrvoje ; Bošnjak, Berislav ; Tomas, Davor ; Krušlin, Božo ; Belicza, Mladen

engleski

TP53, Bcl-2 and growth hormone receptor expression in cutaneous squamous cell carcinoma

The incidence and prevalence of premalignant and malignant skin lesions including squamous cell carcinoma (SCC) of the skin are increasing worldwide. The aim of the study was to determine TP53, Bcl-2 and growth hormone receptor (GHR) expression in SCC and to investigate relative importance of these proto-oncogenes in its biological behavior. Expression of TP53, Bcl-2 and GHR was determined by immunohistochemistry in 27 SCC specimens and adjacent perilesional skin. The relative proportion of immunoreactive cells was counted with semiquantitative method. TP53 positivity was detected in 24 (89%), Bcl-2 in 18 (67%) and GHR in 25 (93%) of 27 SCC specimens investigated. In comparison with perilesional skin, TP53 and GHR positivity was significantly increased, and Bcl-2 positivity significantly decreased in SCC. Increased TP53 expression in SCC lesions implies that Tp53 mutation is an early and crucial event in its development. Increased GHR expression suggests a role of growth hormone in the development of SCC.

TP53; Bcl-2; GHR; squamous cell carcinoma

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Podaci o izdanju

13 (4)

2005.

201-5-x

objavljeno

1330-027X

Povezanost rada

nije evidentirano

Indeksiranost