engleski

The correlation between the tumor necrosis and renal artery changes in renal cell carcinoma

Necrosis, cysts, haemorrhage and calcification represent common findings in renal cell carcinoma (RCC). Different lesions, including arteriosclerosis and/or fibromuscular dysplasia (FMD), may involve the main renal artery. We analyzed the relationship between extent of necrosis in RCC with renal artery changes in a consecutive series of 112 patients (M:F=71:41) with RCC from 2-20 cm (mean 7.7). Necrosis was seen macroscopically and confirmed microscopically in 88 (78.6%) cases, with 64 tumours having less than 50% and 24 more than 50% necrosis. FMD was found in 41 (36.6%) patients (M:F=17:24) and atherosclerotic changes in 21 (18.8%) patients (M:F=18:3). Our results suggest that necrosis of RCC was significantly more common in female patients with associated FMD (especially type-I) and male patients with atherosclerotic changes of renal artery

fibromuscular dysplasia; renal cell carcinoma; renal arteries; necrosis

nije evidentirano