engleski

BMP-7 expression in acute and chronic pyelonephritis in humans

Bone morphogenetic protein-7 (BMP-7) is a member of the transforming growth factor (TGF) beta superfamily and is involved in regeneration, repair, and development of specific tissue, for example kidney and skeleton. The experimental studies have shown its protective role against fibrotic processes. Tubulointestinal changes are present in the pyelonephritic kidney which progress to fibrosis. Renal fibrosis may lead to loss of renal function. The aim of this study was to investigate BMP-7 expression in acute and chronic pyelonephritis in humans. Three patients with acute pyelonephritis and seven with chronic pyelonephritis were treated in Department of Nephrology, Clinical Hospital Rijeka. Tissue biopsy was taken and renal tissue was studied histopathologically by use of hematoxylin and eosin and scored for diagnosis of pyelonephritis. BMP-7 expression was studied by immunohistochemical staining. BMP-7 expression was observed in the tubular area of the pyelonephritic kidneys. The expression of BMP-7 was stronger in the acute pyelonephritic group and more less in the chronic pyelonephritic group of patients. The results imply that BMP-7 has a role in chronic pyelonephritis. Tubular BMP-7 expression had a negative correlation with fibrosis and tubular atrophy.

bone morphohenetic protein-7; acute pyelonephritis; chronic pyelonephritis; immunohistochemistry

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