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Cortical distribution of gangliosides in Alzheimer's disease


Kračun, Ivica; Kalanj, Svjetlana; Talan-Hranilović, Jasna; Ćosović, Čedomir
Cortical distribution of gangliosides in Alzheimer's disease // Neurochemistry International, 20 (1992), 3; 433-438 (međunarodna recenzija, članak, znanstveni)


Naslov
Cortical distribution of gangliosides in Alzheimer's disease

Autori
Kračun, Ivica ; Kalanj, Svjetlana ; Talan-Hranilović, Jasna ; Ćosović, Čedomir

Izvornik
Neurochemistry International (0197-0186) 20 (1992), 3; 433-438

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Brain gangliosides; Alzheimer's disease

Sažetak
In Alzheimer's disease, all ganglio-series gangliosides (GM1, GD1a, GD1b and GT1b) were found to be decreased in temporal and frontal cortex, and nucleus basalis of Meynert. In addition, in Alzheimer's disease simple gangliosides (GM2, GM3) were elevated in frontal and parietal cortex, possibly correlating to accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



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    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE