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Endemic nephropathy and exposure to mycotoxins

Peraica, Maja; Domijan, Ana-Marija
Endemic nephropathy and exposure to mycotoxins // Abstract Book Recent Advances in Endemic Nephropathy, Collegium Antropologicum / Čikeš, Nada ; Jelaković, Bojan (ur.).
Zagreb: Croatian Anthropological Society, 2006. (pozvano predavanje, domaća recenzija, sažetak, znanstveni)

Endemic nephropathy and exposure to mycotoxins

Peraica, Maja ; Domijan, Ana-Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Abstract Book Recent Advances in Endemic Nephropathy, Collegium Antropologicum / Čikeš, Nada ; Jelaković, Bojan - Zagreb : Croatian Anthropological Society, 2006

Recent Advances in Endemic Nephropathy

Mjesto i datum
Zagreb, Hrvatska, 20-22.10.2006.

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Endemic nephropathy; nephrotoxic mycotoxins; ochratoxin A; fumonisin B1; citrinin

The occurrence of endemic nephropathy (EN) in rural population in regions without industry indicates the natural toxic compound as a causative agent. The mycotoxin theory of the development of EN is based on the similarities of pathological kidney lesions in patients with EN and that of pigs in Scandinavian countries. This fact focused the research of EN on the human exposure to the mycotoxin ochratoxin A (OTA), the causative agent of pig nephropathy. OTA is nephrotoxic and carcinogenic compound that fitted well with an unusually high incidence of upper urothelial tumors in patients with EN. In several studies OTA was found either more frequently or in higher concentrations not only in various commodities, but also in blood of persons in endemic region. However, OTA was found very frequently in healthy humans out of endemic region. Various mycotoxins are produced by same genera of moulds, but even one strain may produce different mycotoxins. The co-occurrence of OTA, citrinin and fumonisin B1 (FB1) was found in commodities from endemic regions in Bulgaria and Croatia. Therefore, the possibility of the exposure of humans in the endemic region to various mycotoxins and their combinations seems real. The literature data on combined toxic effects of OTA and other nephrotoxic mycotoxins, such as FB1, penicillic acid (PA), and citrinin, are rather scarce. We have studied the effect of OTA and FB1 on oxidative DNA damage in rat kidney measured with single cell gel electrophoresis (comet assay). In kidney of rats treated with either OTA or FB1 or their combinations tail length and tail intensity of comet assay clearly showed their synergistic genotoxic effect. This effect was seen even after the treatment with the combination of such low doses of OTA and FB1 that are daily human exposure in Europe (5 and 200 ng/kg b.w., respectively). Taken together these results confirm that the simultaneous exposure to different mycotoxins may have impact on human health.

Izvorni jezik

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita


Projekt / tema

Institut za medicinska istraživanja i medicinu rada, Zagreb