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Pregled bibliografske jedinice broj: 260307

Functional elements in satellite DNAs


Pezer, Željka; Brajković, Josip; Ugarković, Đurđica
Functional elements in satellite DNAs // 1st MedILS Summer School "Structure and Evolution: from Bench to Terminal" - Abstract Book / Đikić, Ivan et al. (ur.).
Split: MedILS, 2006. (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 260307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Functional elements in satellite DNAs

Autori
Pezer, Željka ; Brajković, Josip ; Ugarković, Đurđica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
1st MedILS Summer School "Structure and Evolution: from Bench to Terminal" - Abstract Book / Đikić, Ivan et al. - Split : MedILS, 2006

Skup
1st MedILS Summer School "Structure and Evolution: from Bench to Terminal"

Mjesto i datum
Split, Hrvatska, 18-22.07.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
satellite DNA; transcription; noncoding RNA

Sažetak
Satellite DNAs are highly repetitive sequences located in heterochromatic regions of eukaryotic chromosomes. They are usually characterized by rapid evolution of sequence and copy number what leads to their preservation among a limited number of closely related species. Despite such a high turnover satellite DNAs represent main centromere building element strongly associated with a number of proteins forming unique centromeric chromatin. In addition, some satellite DNA transcripts in the form of small interfering RNAs participate in the epigenetic process of chromatin modulation and heterochromatin establishment. Our recent data obtained by studying satellite DNAs of the coleopteran genus Palorus indicate that evolution of satellite sequence is not only driven by stochastic processes as previously proposed, but is influenced by selective constraints. These conclusions are based on extreme interspecific conservation and wide distribution of Palorus satellite sequences among species separated for long evolutionary periods. Their transcriptional activity in the form of multiple transcripts deriving from both DNA strands with approximate size between 5 kb and 1 kb is detected. The transcripts contain poly(A) tails and are present in cytoplasm. Major transcription initiation sites are determined and putative RNA polymerase II promoters are mapped within the satellite repeats. The transcripts are detected in all developmental stages but are the most abundant in adults, indicating their developmental regulation. Since we were not able to detect siRNAs homologous to satellite repeats, it could be proposed that longer transcripts play a role in heterochromatin formation.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekti:
0098074

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju:

Pezer, Željka; Brajković, Josip; Ugarković, Đurđica
Functional elements in satellite DNAs // 1st MedILS Summer School "Structure and Evolution: from Bench to Terminal" - Abstract Book / Đikić, Ivan et al. (ur.).
Split: MedILS, 2006. (poster, međunarodna recenzija, sažetak, znanstveni)
Pezer, Ž., Brajković, J. & Ugarković, Đ. (2006) Functional elements in satellite DNAs. U: Đikić, I. (ur.)1st MedILS Summer School "Structure and Evolution: from Bench to Terminal" - Abstract Book.
@article{article, editor = {\DJiki\'{c}, I.}, year = {2006}, pages = {38}, keywords = {satellite DNA, transcription, noncoding RNA}, title = {Functional elements in satellite DNAs}, keyword = {satellite DNA, transcription, noncoding RNA}, publisher = {MedILS}, publisherplace = {Split, Hrvatska} }
@article{article, editor = {\DJiki\'{c}, I.}, year = {2006}, pages = {38}, keywords = {satellite DNA, transcription, noncoding RNA}, title = {Functional elements in satellite DNAs}, keyword = {satellite DNA, transcription, noncoding RNA}, publisher = {MedILS}, publisherplace = {Split, Hrvatska} }




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