engleski

Salivary nickel and chromium in patients with burning mouth syndrome

The aim of this study was to evaluate the concentrations of nickel and chromium ions in saliva collected from patients complaining of burning mouth syndrome (BMS). Sixty patients were included in this study. They were divided in two groups. The first group consisted of 31 patients with burning mouth syndrome without any observable oral lesions (females=26, men=5, mean age=58.53± ; 14.35) with metal prosthetic appliances or amalgam fillings. The control group consisted of 29 patients without any sensation in oral cavity and with metal prosthetic appliances or amalgam fillings (females= 24, men=5, mean age=51.33± ; 11.61). Unstimulated whole saliva was collected and the level of nickel and chromium were measured using electrothermal atomic absorption spectrometry method. Results: The considerable variations in concentrations of nickel and chromium were observed between the groups. Patients with burning mouth syndrome had significant higher level of nickel (median=6.00 microg/L, range 1.53-64.50 microg/L) compared to the control subjects (median=1.67 microg/L, range 0.12-6.3 microg/L, Man-Whitney U-test p=0.001). Furthermore, Man-Whitney U-test showed significant higher level of chromium in the BMS group (median=2.00 microg/L, range 0.3-22.5 microg/L) compared to the control group (median=1.02 microg/L, range 0.24-2.4 microg/L, p=0.004). Conclusion: Patients with burning mouth sensation had significant higher levels of nickel and chromium comparing to the control group.

saliva; nickel; chromium; atomic absorption spectrometry; burning mouth syndrome

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