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VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION


Foretić, Blaženka; Lovrić, Jasna; Picek, Igor; Burger, Nicoletta
VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION // XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY ; BOOK OF ABSTRACTS / Akyuz, Sevim ; Akalin, Elif (ur.).
Istanbul, 2006. str. 152-152 (poster, nije recenziran, sažetak, znanstveni)


Naslov
VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION

Autori
Foretić, Blaženka ; Lovrić, Jasna ; Picek, Igor ; Burger, Nicoletta

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY ; BOOK OF ABSTRACTS / Akyuz, Sevim ; Akalin, Elif - Istanbul, 2006, 152-152

Skup
XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY

Mjesto i datum
Istanbul, Turska, 03-08.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
FT IR and Raman spectroscopy; UV-VIS spectroscopy; 1-Phenacyl- and 1-Benzoylethylpyridinium derivatives

Sažetak
Pyridinium or bispyridinium oxime derivatives are known as potent acetylcholinesterase reactivators used for the prophylaxis and treatment of intoxications with organophosphorous compounds such as nerve agents and pesticides. Some 1-phenacylpyridinium salts have interesting antifungal and amebacidal properties while 1-benzoylethylpyridinium and 1-benzoylethylpyridinium-4-aldoxime salts act as possible protectors of human blood cholinesterase due to their capability to reversibly inhibit this enzyme. The spectrophotometric studies on the coordination ability of the selected aralkyl derivatives of the pyridinium cation (Table 1) to the pentacyanoferrate(II) moiety have shown considerable differences concerning their stability and reactivity in aqueous solutions. These findings encouraged us to perform a comparative FT IR and FT Raman spectroscopic study of the solid compounds focused on their structural features. Table 1. The examined derivatives of pyridinium chloride Name R1 R2 1-Phenacylpyridinium chloride -CH2- -H 1-Phenacyl-2-methylpyridinium chloride -CH2--CH3 1-Phenacylpyridinium-4-aldoxime chloride-CH2- -C=N-OH 1-Benzoylethylpyridinium chloride -CH2CH2- -H 1-Benzoylethylpyridinium-4-aldoxime chloride -CH2CH2- -C=N-OH The characteristic vibrational frequencies will be discussed in correlation to their predominant keto-enol form, acido-basic properties, and in comparison with the electronic spectra of the ligands themselves and their pentacyanoferrate(II) complexes.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0108051

Ustanove
Medicinski fakultet, Zagreb

Profili:

Avatar Url Blaženka Foretić (autor)

Avatar Url Nicoletta Burger (autor)

Avatar Url Jasna Lovrić (autor)

Avatar Url Igor Picek (autor)

Citiraj ovu publikaciju

Foretić, Blaženka; Lovrić, Jasna; Picek, Igor; Burger, Nicoletta
VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION // XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY ; BOOK OF ABSTRACTS / Akyuz, Sevim ; Akalin, Elif (ur.).
Istanbul, 2006. str. 152-152 (poster, nije recenziran, sažetak, znanstveni)
Foretić, B., Lovrić, J., Picek, I. & Burger, N. (2006) VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION. U: Akyuz, S. & Akalin, E. (ur.)XXVIII EUROPEAN CONGRESS ON MOLECULAR SPECTROSCOPY ; BOOK OF ABSTRACTS.
@article{article, year = {2006}, pages = {152-152}, keywords = {FT IR and Raman spectroscopy, UV-VIS spectroscopy, 1-Phenacyl- and 1-Benzoylethylpyridinium derivatives}, title = {VIBRATIONAL AND ELECTRONIC SPECTRAL CHARACTERISATION OF SEVERAL PHARMACOLOGICALLY IMPORTANT ARALKYL DERIVATIVES OF THE PYRIDINIUM CATION}, keyword = {FT IR and Raman spectroscopy, UV-VIS spectroscopy, 1-Phenacyl- and 1-Benzoylethylpyridinium derivatives}, publisherplace = {Istanbul, Turska} }