engleski

Synthesis and Biological Activity of Phencyclidine and its Adamantylamine Derivatives

1-(2-Phenil-2-adamantil)amines 2a-c were synthesized and their biological activity evaluated by in vitro testing of their effects on the proliferative and reproductive ability of a human tumor cell strain and nonmalignant mouse and hamster fibroblast in culture, and these effects compared with those of phencyclidine 1. Experiments with asynchronously growing cell populations revaled inhibition of poliferation in both normal and malignant cell strains in the presence of 0, 00001M 1 and of morfoline derivative 2c. However, there were no changes in growth rate in the presence of the 2 adamantil derivatives 2a and 2b. Reduction of survival in both normal and malignant cell strains was also observed, but at higher concentrations and with less toxic side effexcts of 2a and 2b. Combined effects of the adamantyl derivatives 2a-c and ionizing irradiation were also studied by determination of cell survival. No radiation-modifying effect was observed. Investigation of these compaunds in mice showed significantly less toxicity and enhanced anestetic effect of the adamantyl derivatives 2a-b than of phencyclidine itself.

phenilcyclidine ; adamantylamine derivatives ; synthesis ; biological activitiy ; cytotoxicity ; cell-proliferation inhibition ; anesthetic effect

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