engleski

Ligation of low-density CD3 molecules on R1.1 cell line leads to modulation of Fas-receptor (CD95)

R1.1 cell-line, originating from mouse thymoma, due to its constitutive expression of kappa opioid receptors (KOR), could be a model for studying the role of kappa opioids in differentiation, maturation, and activation of T lymphocytes in the thymus. In order to use the R1.1 as a model for differentiation studies, the stage of its maturity was characterised by using specific monoclonal antibodies against differentiation antigens of thymus cells. The data obtained have shown that R1.1 cells represent a very immature stage of T-cell differentiation, expressing low density CD3 and CD4, and no CD8. Due to CD3, R1.1 cells are able to respond to activation by anti-CD3 antibody, in spite of their immature phenotype.

T lymphocytes; CD3; activation; Fas-receptor; kappa opioid receptor

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