Ionization, lipophilicity and solubility properties of repaglinide (CROSBI ID 125375)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mandić, Zoran ; Gabelica, Vesna
engleski
Ionization, lipophilicity and solubility properties of repaglinide
Potentiometric and spectrophotometric titrations were used for the determination of ionization behviour, lipophilicity and solubility profile of repaglinide. Acid-base equilibria were characterized by means of protonation macro- and microconstants using Target Factor Analysis of spectrophotometric data. Lipophilicity profiles were evaluated by determination of partition coefficients of neutral and ionized forms of repaglinide in biphasic octanol/water system. The intrinsic solubility of repaglinide were determined from the solubility data and temperature dependence of intrinsic solubilities were evaluated using van't Hoff equation.
repaglinide ; acid-base properties ; ionization macro- and microconstants ; lipophilicity ; solubility
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Podaci o izdanju
41 (3)
2006.
866-871
objavljeno
0731-7085
1873-264X
10.1016/j.jpba.2006.01.056
Povezanost rada
Kemija, Kemijsko inženjerstvo