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Pregled bibliografske jedinice broj: 257769

PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells.


Martin-Kleiner, Irena; Svoboda-Beusan, Ivna; Gabrilovac, Jelka
PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells. // Immunopharmacology and Immunotoxicology, 28 (2006), 411-420 (međunarodna recenzija, članak, znanstveni)


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Naslov
PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells.

Autori
Martin-Kleiner, Irena ; Svoboda-Beusan, Ivna ; Gabrilovac, Jelka

Izvornik
Immunopharmacology and Immunotoxicology (0892-3973) 28 (2006); 411-420

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
pre-B leukemic cells; CD10; NALM-1; PMA; doxorubicin

Sažetak
PMA 10, 20 ng/ml) and doxorubicin (5-20 ng/ml) decreased the viability and MTT-activity of NALM-1 pre-B leukemic cells (3 days treatment). Further, CD10 was downregulated, suggesting that PMA and doxorubicin induced differentiation of NALM-1 cells. However, PMA did not alter expression of B cell markers CD20 and of mIgM. In contrast to PMA, another differentiation agent ATRA did not alter CD10 expression on NALM-1 cells but affected viability after 6 days (5, 10 ng/ml). The data on this study are the first evidence that PMA and doxorubicin inhibited viability and MTT activity and induced partial differentiation, by decreasing CD10 on NALM-1 cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
0098094

Ustanove:
Institut "Ruđer Bošković", Zagreb


Citiraj ovu publikaciju

Martin-Kleiner, Irena; Svoboda-Beusan, Ivna; Gabrilovac, Jelka
PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells. // Immunopharmacology and Immunotoxicology, 28 (2006), 411-420 (međunarodna recenzija, članak, znanstveni)
Martin-Kleiner, I., Svoboda-Beusan, I. & Gabrilovac, J. (2006) PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells.. Immunopharmacology and Immunotoxicology, 28, 411-420.
@article{article, year = {2006}, pages = {411-420}, keywords = {pre-B leukemic cells, CD10, NALM-1, PMA, doxorubicin}, journal = {Immunopharmacology and Immunotoxicology}, volume = {28}, issn = {0892-3973}, title = {PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells.}, keyword = {pre-B leukemic cells, CD10, NALM-1, PMA, doxorubicin} }
@article{article, year = {2006}, pages = {411-420}, keywords = {pre-B leukemic cells, CD10, NALM-1, PMA, doxorubicin}, journal = {Immunopharmacology and Immunotoxicology}, volume = {28}, issn = {0892-3973}, title = {PMA and doxorubicin decrease viability, MTT activity, and expression of CD10 marker on NALM-1 leukemic cells.}, keyword = {pre-B leukemic cells, CD10, NALM-1, PMA, doxorubicin} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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