engleski

Effect of morphologic cell types on the expression of bcl-2, ki-67 and p-53 in uveal melanomas.

Uveal melanomas are known to be less aggressive malignant tumors compared with melanoma of other localisations but the same morphologic characteristics.We hypothezised that immunohistochemical determination of expression of the known proliferation markers bcl-2, ki-67and p-53 as a supressor gene marker, could better explain the biological behavior of uveal melanoma vs. melanoma of other localisations.Thirty cases of primary uveal melanoma of two levels of invasion were tested retrospectively for the presence of bcl-2, Ki-67 andp-53 proteins with with the indirect peroxidase-antiperoxidase immunoenzyme method and three step ABC/AP method.The intensity of reaction was assessed by semiquantitative method.

bcl-2oncoprotein; Ki-67 oncogene; p-53supressor gene; uveal melanoma

Rad je prezentiran na skupu 13th Ljudevit Jurak International Symposium of Comporative Pathology, održanom od 07.-98.07.2002., Zagreb, Hrvatska.