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Binding of indole-3-acetic acid derivatives to serum albumin


Šoškić, Milan; Magnus, Volker
Binding of indole-3-acetic acid derivatives to serum albumin // Proceedings of Abstracts (Zbornik sažetaka), 9th Croatian Biological Congress / Besendorfer, Višnja ; Filipović, Indira (ur.).
Zagreb: Hrvatsko biološko društvo 1885, 2006. str. 194-195 (poster, nije recenziran, sažetak, znanstveni)


Naslov
Binding of indole-3-acetic acid derivatives to serum albumin

Autori
Šoškić, Milan ; Magnus, Volker

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Proceedings of Abstracts (Zbornik sažetaka), 9th Croatian Biological Congress / Besendorfer, Višnja ; Filipović, Indira - Zagreb : Hrvatsko biološko društvo 1885, 2006, 194-195

Skup
9th Croatian Biological Congress (9. Hrvatski biološki kongres)

Mjesto i datum
Rovinj, Hrvatska, 23.-29.09.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
ring-substituted indole-3-acetic acid; IAA; human serum albumin; HSA; substituent effect on ligand binding; structure-affinity relationship

Sažetak
Auxins, in coordination with other plant hormones, regulate practically all aspects of plant growth and development. However, the mechanism of auxin action is still poorly understood. The main goal of this study was to explore the interactions of indole-3-acetic acid and its derivatives with human serum albumin as a model protein. It is known that serum albumins specifically bind indolic compounds and, in their amino acid sequences, share certain analogies with some auxin-binding proteins of plant origin. Correlation of the relative binding constants of indole-3-acetic acids to serum albumin with structural and physico-chemical descriptors reveals that affinities are dominantly influenced by hydrophobic interactions. As a rule, more lipophilic auxins bind more strongly than more polar analogues. Alkyl groups at indole ring position 2 obstruct proper orientation of the molecules within the binding site, while substituents at position 6, if more voluminous than fluorine, favor strong binding to the protein. Electron withdrawing substituents enhance the binding affinities of these compounds for the protein. Esterification of the carboxyl group as well as methylation of the indole-ring nitrogen does not lead to drastically reduced binding affinities. Comparison of the binding constants of indole-3-acetic acids to human serum albumin with their growth promoting activities in Avena coleoptiles indicates that the putative plant receptor is sterically more demanding.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija



POVEZANOST RADA


Projekt / tema
0098080
0178067

Ustanove
Institut "Ruđer Bošković", Zagreb,
Agronomski fakultet, Zagreb

Profili:

Avatar Url Volker Magnus (autor)

Avatar Url Milan Šoškić (autor)

Citiraj ovu publikaciju

Šoškić, Milan; Magnus, Volker
Binding of indole-3-acetic acid derivatives to serum albumin // Proceedings of Abstracts (Zbornik sažetaka), 9th Croatian Biological Congress / Besendorfer, Višnja ; Filipović, Indira (ur.).
Zagreb: Hrvatsko biološko društvo 1885, 2006. str. 194-195 (poster, nije recenziran, sažetak, znanstveni)
Šoškić, M. & Magnus, V. (2006) Binding of indole-3-acetic acid derivatives to serum albumin. U: Besendorfer, V. & Filipović, I. (ur.)Proceedings of Abstracts (Zbornik sažetaka), 9th Croatian Biological Congress.
@article{article, year = {2006}, pages = {194-195}, keywords = {ring-substituted indole-3-acetic acid, IAA, human serum albumin, HSA, substituent effect on ligand binding, structure-affinity relationship}, title = {Binding of indole-3-acetic acid derivatives to serum albumin}, keyword = {ring-substituted indole-3-acetic acid, IAA, human serum albumin, HSA, substituent effect on ligand binding, structure-affinity relationship}, publisher = {Hrvatsko biolo\v{s}ko dru\v{s}tvo 1885}, publisherplace = {Rovinj, Hrvatska} }