engleski

First report of CTX-M-extended-spectrum beta-lactamase- producing isolates from Croatia

Five clinical Escherichia coli isolates from University Hospital Split, Croatia, with a CTX-M resistance phenotype (high level of resistance to cefotaxime and ceftriaxone) were screened for blaCTX-M alleles by PCR and confirmed to produce a group 1 CTX-M enzyme. ESBL phenotype was transferred by conjugation from 3 isolates to a rifampicin-resistant recipient strain. PFGE proved that two of these five strains were clonally related. This is the first report from Croatia of CTX-M type enzyme. Carbapenems could be recommended as antibiotics of choice for the treatment of infections caused by our CTX-M producing E. coli isolates.

extended-spectrum beta-lactamases; CTX-M-beta-lactamases; Escherichia coli; cefotaxime

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