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Synthesis, spectroscopy and biological activity of palladium(II) acetate complexes with quinolylmethylphosphonates

There is a current interest in platinum(II) and palladium(II) complexes with nitrogen donor ligands not only because of their wide-range application in organic synthesis and catalysis, but also owing to their biological and pharmacological importance. A number of these compounds have shown good cell growth inhibitory effects. In this field our study is directed to complexes of quinoline and aniline-based alkyl phosphonates. We report here the synthesis, some spectroscopic properties and biological evaluation of new palladium(II) acetate complexes of diethyl 8-quinolylmethylphosphonate and monoethyl 2-quinolylmethylphosphonate (2-Hmqmp). These organophosphorus ligands form different type of binuclear acetate-bridged complex, that with [C, N] and [N, O] cyclopalladation, respectively. Comparative studies were performed with results obtained for the selected palladium(II) chloride complexes of the same phosphonate ligands and a structure-activity relationship was discussed. It was found that most of complexes demonstrated distinct in vitro cytostatic activity, but showed no or only marginal antiviral activity in different assay systems.

palladium(II) acetate complexes; quinolylmethylphosphonate complexes; antitumor and antiviral activity

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