engleski

Lack of Proper Follicular Dendritic Cells Networks May Prevent Germinal Center Formation in both Bcl-3 and p52 KO Mice

Maturation of FDC is impaired in mice deficient in p52, a subunit of NF-kB transcription factors, as well as in mice deficient in Bcl-3, a regulator of NF-kB activity. However, while the formation of FDC networks is only partially affected in Bcl-3 KO mice, this network is completely missing in p52 Kos. Consistent with loss of FDC networks, memory response appear to be defective in both mice. Adoptive transfer of wild type bone marrow cells into p52 recipients failed to restore the ability to form FDC networks, suggesting a critical defect in nonhematopoietic/stromal cell compartment in both knockout mice. Potentially related to this defect in stromal cells, we observed impaired extracellular matrix formation in the marginal zone of p52 KO spleens.

Germinal center; follicular dendritic cells; NF-Kb activation

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