engleski

Critical role for p52 containing NF-kB complexes in fomration of follicular dendritic cell networks

Follicular dendritic cells(FDCs)are antigen repesenting cells located in B cell zones of secondary lymphoid organs.They do not process antigen, instead can capture antigen in its native form and present it for prolonged periods, a function thought to be important for generation of memory response. The cellular origin of FDC and their maturation to cells forming networks in response to antigen remains to be defined. Maturation of FDCs is impaired in mice deficient in p52, a subunit of NF-kB transcription factors, as well as in mice deficient in Bcl-3, a regulator of NF-kB activity. However, while the formation of FDC networks is only partially affected in Bcl-3 KO mice, this network is completely missing in p52 KOs. Consistent with loss of FDC networks, memory response appear to be defective in both mice. Adoptive transfer of wild-type bone marrow cells into p52 recipients failed to restore the ability to form FDC networks, suggesting a critical defect in a non-hematopoietic/stromal cell compartment in both knock-out mice. Potentially related to this defect in stromal cells, we observed impaired extracellular matrix formation in the marginal zone of p52 KO spleens.

follicular dendritic cells; NF-kB complexes; genes activation

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