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Pregled bibliografske jedinice broj: 256049

Interleukin-10 expression in sporadic colon cancer


Čačev, Tamara; Kapitanović Sanja
Interleukin-10 expression in sporadic colon cancer // Zbornik 9.Hrvatskog biološkog kongresa / Besendorfer, Višnja ; Klobučar, Goran (ur.).
Zagreb: Hrvatsko biološko društvo 1885, 2006. str. 91-93 (pozvano predavanje, domaća recenzija, pp prezentacija, znanstveni)


Naslov
Interleukin-10 expression in sporadic colon cancer

Autori
Čačev, Tamara ; Kapitanović Sanja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Izvornik
Zbornik 9.Hrvatskog biološkog kongresa / Besendorfer, Višnja ; Klobučar, Goran - Zagreb : Hrvatsko biološko društvo 1885, 2006, 91-93

Skup
9. Hrvatski biološki kongres s međunarodnim sudjelovanjem

Mjesto i datum
Rovinj, Hrvatska, 23.9.-29.9.2006

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Interleukin-10; sporadic colon cancer

Sažetak
Interleukin 10 (IL-10) is cytokine with potent anti-inflammatory and immunosuppressive activity. The role of this pleiotropic cytokine in tumor immunology is controversial. Expression of IL-10 mRNA was observed in a variety of human tumors including ovarian, breast, renal cell, lung and skin carcinomas. Several human tumor cell lines from colon, lung and skin carcinomas produce IL-10. The biological significance of IL-10 production by tumor cells remains unexplored. There is conflicting evidence about its influence on cancer. Dependent of the experimental model it seems to favour or inhibit the existence and progression of tumors. In some cases it may act as tumor growth factor or as immunosuppressive molecule secreted by tumors to escape from immune surveillance, but in some cases it has also been shown to posses immunostimulating and antitumor properties. IL-10 was also shown to inhibit tumor angiogenesis and invasiveness. In order to elucidate its influence on sporadic colon cancer we have analyzed IL-10 protein expression in 100 sporadic colon tumor tissue samples by immunohistochemistry. In 50 sporadic colon tumor tissue samples as well as corresponding normal mucous tissue mRNA expression was analyzed by real-time quantitative RT-PCR. IL-10 mRNA expression was lower in tumor tissue samples then in corresponding normal mucous tissue and this difference was found to be statistically significant. IL-10 protein expression was reduced in tumors classified as Dukes’ C and poorly differentiated tumors. Thus, we may conclude that reduced expression of IL-10 in sporadic colon cancer may point to its inhibitory role in progression of colon tumors.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098108

Ustanove
Institut "Ruđer Bošković", Zagreb