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Performance of Brush-Type HPLC Chiral Stationary Phases with Tertiary Amide in the Connecting Tether


Moslavac Forjan, Davorka; Kontrec, Darko; Vinković, Vladimir
Performance of Brush-Type HPLC Chiral Stationary Phases with Tertiary Amide in the Connecting Tether // Chirality, 18 (2006), 10; 857-869 (međunarodna recenzija, članak, znanstveni)


Naslov
Performance of Brush-Type HPLC Chiral Stationary Phases with Tertiary Amide in the Connecting Tether

Autori
Moslavac Forjan, Davorka ; Kontrec, Darko ; Vinković, Vladimir

Izvornik
Chirality (0899-0042) 18 (2006), 10; 857-869

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Chiral liquid chromatography; tertiary amide connecting tether; electron-rich shield; enantiomer separation

Sažetak
The replacement of the N— H hydrogen of the secondary amide-tethered Pirkle-concept N-(3, 5-dinitrobenzoyl)-L-leucine derived chiral stationary phase with various p-basic or aliphatic groups improved the chiral discrimination ability of new chiral stationary phases, based on the leucine- or alanine-derived chiral selector, for the enantiomers of various racemic neutral analytes with amide functional groups. Retention times decreased while separation and resolution factors increased, thus proving the role of p-donor aromatic unit as an electron-rich shield in the front of a silica surface. In general, chiral stationary phase (CSP) 5 with the 3, 5-dimethylphenyl unit showed best performance, while CSP 3, with phenyl unit, and CSP 7, with 1-naphthyl unit in the tertiary amide connecting tether, were less efficient.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098051

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE