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Pregled bibliografske jedinice broj: 255480

Are there differences in platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis?


Marčinko, Darko; Pivac, Nela; Jakovljević, Miro; Martinac, Marko; Mihaljević-Peleš, Alma; Topić, Radmila; Muck-Šeler, Dorotea
Are there differences in platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis? // Psychiatria Danubina / Jakovljević, Miro ; Schony, Werner (ur.).
Zagreb: Medicinska naklada, 2006. str. 121-121 (predavanje, međunarodna recenzija, sažetak, znanstveni)


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Naslov
Are there differences in platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis?

Autori
Marčinko, Darko ; Pivac, Nela ; Jakovljević, Miro ; Martinac, Marko ; Mihaljević-Peleš, Alma ; Topić, Radmila ; Muck-Šeler, Dorotea

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Psychiatria Danubina / Jakovljević, Miro ; Schony, Werner - Zagreb : Medicinska naklada, 2006, 121-121

Skup
11th European Symposium on Suicide and Suicidal behaviour

Mjesto i datum
Portorož, Slovenija, 9-12.09.2006

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
platelet serotonin; serum cholesterol; suicidal and non-suicidal male patients; first episode of psychosis

Sažetak
Suicidal behavior is a major risk in schizophrenia, and it is estimated that up to 10% patients will commit suicide. The rate of suicide is more than 20 times higher than that in the general population. It has been reported that up to 40% of patients diagnosed with schizophrenia will have at least one suicide attempt in the course of their illness. The neurobiology of suicide is still unclear. Various studies have attempted to identify the possible peripheral markers that might help in the early detection of suicidal behavior. In addition, evidence is accumulating that a hereditary disposition to suicide exists, that appears to be independent of a diagnosis. While there are a lot of data regarding the biology of suicidality in schizophrenia, the data considering biology of suicidality in the first episode of psychosis are missing. The neurobiology of suicide is still unclear. Suicidality has been related to a decreased central serotonergic (5-hydroxytryptamine, 5-HT) function and reduced cholesterol levels. Platelet 5-HT was used as a peripheral marker of the central serotonergic synaptosomes. The hypothesis was that suicidal patients in the first episode of psychosis will have different serum cholesterol and platelet 5-HT concentrations than non-suicidal patients in the first episode of psychosis. The aim of this study was to evaluate serum cholesterol and platelet 5-HT concentrations in suicidal and non-suicidal men in the first episode of psychosis and in healthy male controls. Venous blood samples were collected within 24 hours of admission, and serum cholesterol and platelet 5-HT were determined enzymatically and fluorimetrically. Platelet 5-HT and serum cholesterol concentrations were significantly lower in suicidal than in non-suicidal patients in the first episode of psychosis than in healthy controls. Our results suggest that lower concentrations of serum cholesterol and platelet 5-HT in patients with the first episode of psychosis might be useful biological markers of suicidality.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
0098088
0108106

Ustanove
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Rijeka

Citiraj ovu publikaciju

Marčinko, Darko; Pivac, Nela; Jakovljević, Miro; Martinac, Marko; Mihaljević-Peleš, Alma; Topić, Radmila; Muck-Šeler, Dorotea
Are there differences in platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis? // Psychiatria Danubina / Jakovljević, Miro ; Schony, Werner (ur.).
Zagreb: Medicinska naklada, 2006. str. 121-121 (predavanje, međunarodna recenzija, sažetak, znanstveni)
Marčinko, D., Pivac, N., Jakovljević, M., Martinac, M., Mihaljević-Peleš, A., Topić, R. & Muck-Šeler, D. (2006) Are there differences in platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis?. U: Jakovljević, M. & Schony, W. (ur.)Psychiatria Danubina.
@article{article, year = {2006}, pages = {121-121}, keywords = {platelet serotonin, serum cholesterol, suicidal and non-suicidal male patients, first episode of psychosis}, title = {Are there differences in platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with first episode of psychosis?}, keyword = {platelet serotonin, serum cholesterol, suicidal and non-suicidal male patients, first episode of psychosis}, publisher = {Medicinska naklada}, publisherplace = {Portoro\v{z}, Slovenija} }