Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Strategy for mapping quantitative trait loci (QTL) by using human metapopulations (CROSBI ID 124878)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Rudan, Igor ; Biloglav, Zrinka ; Carothers, Andrew D. ; Wright, Alan F. ; Campbell, Harry Strategy for mapping quantitative trait loci (QTL) by using human metapopulations // Croatian medical journal, 47 (2006), 4; 532-542-x

Podaci o odgovornosti

Rudan, Igor ; Biloglav, Zrinka ; Carothers, Andrew D. ; Wright, Alan F. ; Campbell, Harry

engleski

Strategy for mapping quantitative trait loci (QTL) by using human metapopulations

AIM: To present a novel strategy for mapping quantitative trait loci (QTL), using human metapopulations. The strategy is based on the expectation that in geographic clusters of small and distinct human isolates, a combination of founder effect and genetic drift can dramatically increase population frequency of rare QTL variants with large effect. In such cases, the distribution of QT measurements in an (affected) isolate is expected to deviate from that observed in neighboring isolates. METHODS: We tested this hypothesis in 9 villages from a larger Croatian isolate resource, where 7 Mendelian disorders have been previously reported. The values of 10 physiological and biochemical QTs were measured in a random sample of 1001 individuals (100 inhabitants of each of 9 villages and 101 immigrant controls). RESULTS: Significant over- or under- representation of individuals from specific villages in extreme ends of standardized QT measurement distribution was found 10 times more frequently than expected by chance. The large majority of such clusters of individuals with extreme QT values (34/36, 94.4%) originated from the 6 villages with the most pronounced geographic isolation and endogamy. CONCLUSION: Early epidemiological assessment supports the feasibility of the proposed strategy. Clusters of individuals with extreme QT values responsible for over-representation of single villages can usually be linked to a larger pedigree and may be useful for further QTL mapping, using linkage analysis.

quantitative trait loci; human isolates; gene mapping; metapopulation

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

47 (4)

2006.

532-542-x

objavljeno

0353-9504

Povezanost rada

Temeljne medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Indeksiranost