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Attempts of enentioselective synthesis of S-(-)-(3-hydroxyphenyl)-1-propylpiperidine (3-PPP)

Two pairs of structural isomers 2, 3 and 4, 5 possessing 2, 3- and 3, 4-double bond in tetrahydropyridine ring, were synthesized and their enantioselective hydrogenation attempted. This represents an attempt to enentioselective synthesis of S-(-)-3-PPT 1, a selective agonist at central dopamine receptors.

enantioselective hydrogenation; dopamine receptors

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