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Pregled bibliografske jedinice broj: 255078

Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase


Majerić Elenkov, Maja; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B.
Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase // Organic Letters, 8 (2006), 19; 4227-4229 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 255078 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase

Autori
Majerić Elenkov, Maja ; Tang, Lixia ; Hauer, Bernhard ; Janssen, Dick B.

Izvornik
Organic Letters (1523-7060) 8 (2006), 19; 4227-4229

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
sequential kinetic resolution; halohydrin dehalogenase; cyanide

Sažetak
A sequential kinetic resolution catalyzed by halohydrin dehalogenase was employed for the synthesis of two valuable enantiopure building blocks. Resolution of methyl 4-chloro-3-hydroxybutanoate methylester using a Trp249Phe mutant of halohydrin dehalogenase yielded methyl 4-cyano-3-hydroxybutanoate methylester with 96.8% ee (40% yield) and methyl 4-chloro-3-hydroxybutanoate methylester with 95.2% ee (41% yield). This reaction is carried out in aqueous solution under mild conditions and provides access to a useful statin side-chain building block

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
0098050

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Majerić-Elenkov (autor)


Citiraj ovu publikaciju:

Majerić Elenkov, Maja; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B.
Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase // Organic Letters, 8 (2006), 19; 4227-4229 (međunarodna recenzija, članak, znanstveni)
Majerić Elenkov, M., Tang, L., Hauer, B. & Janssen, D. (2006) Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase. Organic Letters, 8 (19), 4227-4229.
@article{article, year = {2006}, pages = {4227-4229}, keywords = {sequential kinetic resolution, halohydrin dehalogenase, cyanide}, journal = {Organic Letters}, volume = {8}, number = {19}, issn = {1523-7060}, title = {Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase}, keyword = {sequential kinetic resolution, halohydrin dehalogenase, cyanide} }
@article{article, year = {2006}, pages = {4227-4229}, keywords = {sequential kinetic resolution, halohydrin dehalogenase, cyanide}, journal = {Organic Letters}, volume = {8}, number = {19}, issn = {1523-7060}, title = {Sequential Kinetic Resolution Catalysed by Halohydrin Dehalogenase}, keyword = {sequential kinetic resolution, halohydrin dehalogenase, cyanide} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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  • Chemical Abstracts





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