engleski

Early assessment of mild cognitive decline in patients with cerebrovascular disease

Discrete signs of cognitive decline are known to exist in preclinical dementia of both Alzheimer's or vascular type. The importance of cerebrovascular risk (CVR) factors in the pathogenesis of dementia of both types is stresses by the results of recent studies. Patinets with first ever stroke or TIA (N=110) and asymptomatic subjects-controls (CGs) with cerebrovascular risk factors (N=45) were tested using MMSE and Montreal Cognitive Assessment (moCA) on addmition, at three and six-months points. In all subjects initial MMSE was normal, while in 52 PGs and 11 CGs initial MoCA score was decreased (26 points). Cognitive performance on MMSE for both groups throught the study period fell within the normal range, while MoCA scores revealed cognitive abnormalities. after three months in PGs, and after six months in PGs and CGs. intra-group differences in cognitive decline were statistically significant for PGs with stroke/ multiple risk factors and PGs with TIA., PGs with stroke and PGs with TIA. There was no significant difference in MMSE for PGs with stroke and PGs with TIA and MoCA in PGs with TIA and MoCA in CGs (p=0, 053). MoCA enables early detection of mild cognitive changes in symptomatic patients with cerebrovascular disease, but also in asymptomatic individuals with increased cerebrovascular risk in whom strong medical control of modifiable vascular factors may prevent occurence of severe dementia.

Cerebrovascular disease; Cognitive impairment; MMSE; MoCA

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