engleski

Factor V Leiden and prothrombin polymorphism are not risk factor for stroke in elderly

Conventional stoke risk factors are age, gender, hypertension, smoking and diabetes mellitus, while it is still undetermined whether genetic polymorphisms in coagulation genes can be considered as risk factors. We hypothesize that genetic risk factors are associated with stroke in elderly. Aim of this study was to evaluate association of factor V Leiden and factor II G20210A polymorphisms vs. conventional risk factors in development of stroke. In a retrospective case-control study, we evaluated 63 patients and 61 controls. Stroke in patients was diagnosed by color imaging techniques. Control individuals were age and sex matched with cases and free of past and present CVI events. Information about conventional risk factors was collected from the medical history and interview. Multiple logistic regression analysis was used to identify significant predictors of stroke. Demographic and other characteristic of the patient and control group were as follows: age 70&plusmn ; 9 vs. 71&plusmn ; 7 (P = 0, 834) ; proportion of female patients 29/63 vs. 39/61 (P = 0, 067) ; hypertension 54/63 vs. 37/61 (P = 0, 003) ; smoking 8/63 vs. 5/61 (P = 0, 539) ; diabetes mellitus 14/63 vs. 6/61 (P = 0, 116) ; factor II heterozygotes 3/63 vs. 3/61 (P = 0, 680) ; factor V Leiden heterozygotes 3/63 vs. 3/61 (P = 0, 680). Significant predictors of stroke were hypertension (p=0, 001 ; OR=4, 518, 95% CI=1, 817-11, 231) and male gender (P=0, 020 ; OR=2, 502 95% CI= 1, 154 - 5, 427). Whereas all other variables, including factor II and factor V polymorphisms were of no significance. After age adjustment, these variables remained significant: hypertension (p=0.001 ; OR=4, 771 95% CI=1, 884-12, 081) and male gender (P=0, 017 ; OR= 2, 593, 95% CI=1, 183 - 5, 682). Our study showed that male gender and hypertension, but not hereditary thrombophilia are associated with stroke in elderly.

stroke; factor II; factor V Leiden; polymorphism

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