Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R, 3S)-3-phenylisoserine, and its analogs via chiral 3-hydroxy-4-aryl-beta-lactams through chiral ester enolate-imine cyclocondensation (CROSBI ID 124750)
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Podaci o odgovornosti
Ojima, Iwao ; Habuš, Ivan ; Zhao, Mangzhu ; Georg, Gunda I. ; Jayasinghe, Lalith R
engleski
Efficient and practical asymmetric synthesis of the taxol C-13 side chain, N-benzoyl-(2R, 3S)-3-phenylisoserine, and its analogs via chiral 3-hydroxy-4-aryl-beta-lactams through chiral ester enolate-imine cyclocondensation
A highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-beta-lactams with >96% ee is successfully applied to the asymmetric synthesis of the enentiomerically pure taxol C-13 side chain, N-benzoyl-(2R, 3S)-3-phenylisoserine, and its analogues.
taxol ; chiral ester ; enolate-imine
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