engleski

Immunostimulating and antitumor properties of adamantyltripeptides

Biological activity of two novel adamantyltripeptides, D-(adamant-2-yl)-glycyl-L-alanyl-D-isoglutamine (AdTP1) and L-(adamant-2-yl)-glycyl-L-alanyl-D-isoglutamine (AdTP2) was studied. Immunostimulating activity was detected in mice immunized with sheep red blood cells and in rabbits immunized with human IgG. Isomer 2 exhibited higher immunostimulating affect. Antimetastatic acitivty of both isomers was observed in mice bearing melanoma B-16.

Adamantyltripeptides; B-16 melanoma; antimetastatic activity; immunostimulating activity

nije evidentirano