engleski

Oligonucleotides containing acyclic nucleoside analogues with carbamate internucleoside linkages

Synthesis of 2'-deoxy-2', 3'-secothymidine t and its dimer t*t, where the two 2'-deoxy-2', 3'-secothymidine t units are connected via a carbamate, *=3'-NH-CO-O-5', internucleoside linkage has been achieved. These building blocks were protected in the 5'-position, converted into their phosphoramidites, or attached onto CPG, and then used for ''chimeric oligonucleotide'' synthesis.

2'-deoxy-2' ; 3'-secothymidine t ; internucleoside linkage ; ''chimeric oligonucleotide''

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