Improved synthesis of oligonucleoside methylphosphonate analogs (CROSBI ID 124724)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Habuš, Ivan ; Devlin, Theresa ; Iyer, Radhakrishnan P. ; Agrawal, Sudhir
engleski
Improved synthesis of oligonucleoside methylphosphonate analogs
Solid-phase synthesis using pent-4-enoyl nucleoside PNT phosphonamidites allow for the facile preparation of oligonucleoside methylphosphonates, methylphosphonothioates and their chimeric analogs. With PNT phosphonamidites, nucleobase and phosphate deprotection, as well as, cleavage from the support can all be accomplished by treatment of the support-bound oligonucleotide with NH4OH (28%, rt, 1 h).
oligonucleoside methylphosphonates; methylphosphonothioates
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Arhitektura i urbanizam, Farmacija