engleski

Eccrine carcinoma and nepfrosklerosis in a Asian Elephant (Elephas maximus) : case report

A case eccrine carcinoma of the inerdigital glands and nephrosclerosis followed with uremia in the 39-year-old female Asian elephant from Zagreb zoo in described. The tumor from the area between toenails of the right forefoot was surgically removed three years ago (2003.) and the histopathological diagnosis was eccrine carcinoma. During the last year the animal showed signs of kidney inusfitienty which was followed with sudden deat (2006). At postmortem severe nephrosclerosis of the both kondeys, lung edema, heart dilatation with hydropericardium, gastric healed and recent ulcers, liver fibrosis and atrophy of the lymphnodes and spleen was noted. Histopathologically, extripated tumor was compound eccrine carcinoma of the interdigital glands. Necrosis, papillary intraacrinary proliferation were seen. Mitoses were rarely noted. Previous excision was ssuccesfull because no sign of that tumor was noted on the necropsy. Diffuse glomerular and tubular sclerosis with signs of purulent inflamation of the collecting ducts and micronephrolithiasis, severe lung edema, vascuolisation and lipofuscinosis of the myocardial cells, lymphocitic depletion in the splen and lymphonodes, pancreatic atrophy with adenomatous hyperplasia of the islet-cells, interstitial hepatitis and gastric ulceration were found. In the dermal parts of the foot necrotic vasculitis with thrombosis was also noted. It should be notead also that BUN nad creatinine were significantly elevated (blood urea nitrogen 55, 6 /2.165 mmol/l, creatinine 443/141, 44 mmol/l).

carcinoma; nephrosclerosis; Asian Elephant

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