engleski

The Role of Corticosteroids and Cyclosporin A in Prevention of Corneal Graft Rejection

The most frequently mentioned postkeratoplasty complication is corneal graft rejection, caused by introduction of different tissue antigens into the organism. The cornea is considered as "immunologicaly privileged" part of the eye, because of the absence of blood and lymphatic vessels in the healthy cornea (the afferent and efferent limb for immune reaction lacks), and also because of the phenomena called ACAID (Anterior Chamber Associated Immune Deviation), which main characteristic is a cellular immunity depression. In spite of appearance of new generations of immunosuppressors, corticosteriod therapy is the most frequently used for maintenance of keratotranspalntat and prevention of rejection. Another drug which is today more frequently in use is Cyclosporin A (CsA), a potent immunosupresive agent isolated from certain fungi soil.

Corneal transplantation; Corticosteroids; Cyclosporin A

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