engleski

Effects of L-(2 adamantyl)-glycyl-L alanyl-D-isoglutamine hydrochloride on MCa mammary carcinoma

Two new adamantyl-peptides, D-(2-adamantyl)-glycyl-L-alanyl-D-isoglutamine hydrochloride (isomer 1) and L-(2-adamantyl)-glycyl-L-alanyl-D-isoglutamine hydrochloride (isomer 2) , were tested in the model of the MCa mammary carcinoma of CBA mouse. These compounds, particularly Isomer 2, showed to be more effective in reducing lung metastasis than primary tumor growth and to be active in conditions in which a low number of metastases are formed, a condition that is seen when the tumor is implanted s.c. or when its growth is slowed down by the lower inoculum size.

Adamantyltripeptide; mammary carcinoma; metastasis

nije evidentirano