engleski

The Electrochemical and Molecular Dynamics Study of Aliphatic-Aliphatic Interactions in Copper(II) Amino acid Complexes

Copper amino acidates are considered to be good models of active sites of copper containing redox enzymes. This paper deals with the cyclic voltammetry of bis-copper complexes with aliphatic L-amino acids and their N-dimethyl derivatives in aqueous solution. The influence of N-dimethyl substitutents and of aliphatic amino acid residues on the redox behaviour of the complexes were investigated under physiological conditions (0.15 mol/L). All studied complexes showed two-electron and quasi-reversible electrochemical reactions. Lower stabilities deduced from the redox potential were obtained for the dimethylated than for unsubstitued copper complexes, as we expected [1]. However, bis(L-leucinato)copper(II) showed the lowest stability and its N, N-dimethyl derivative the highest stability among the complexes with natural and dimethylated amino acids, respectively. To examine whether different electrochemical behaviour can be explained with sterical reasons and aliphatic-aliphatic interactions, the molecular dynamics calculations using the force field developed for copper(II) amino acidates [2] are attempted in aqueous medium.

steric hindrance; force field; cyclic voltammetry

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