Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 253877

Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases


Janssen, Dick; Majerić Elenkov, Maja; Hasnaoui, Ghannia; Hauer, Bernhard; Lutje Spelberg, Jeffrey
Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases // Biochemical Society Transactions, 34 (2006), 2; 291-295 (međunarodna recenzija, pregledni rad, znanstveni)


CROSBI ID: 253877 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases

Autori
Janssen, Dick ; Majerić Elenkov, Maja ; Hasnaoui, Ghannia ; Hauer, Bernhard ; Lutje Spelberg, Jeffrey

Izvornik
Biochemical Society Transactions (0300-5127) 34 (2006), 2; 291-295

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
biocatalysis; azide; cyanide; epoxide; halohydrin dehalogenase

Sažetak
Halohydrin dehalogenases catalyze the conversion of vicinal halohydrins to their corresponding epoxides, while releasing halide ions. They can be found in several bacteria that use halogenated alcohols or compounds that are degraded via halohydrins as a carbon source for growth. Biochemical and structural studies have shown that halohydrin dehalogenases are evolutionary and mechanistically related to enzymes of the short-chain dehydrogenase/reductase (SDR) superfamily. In the reverse reaction, which is epoxide-ring opening, different nucleophiles can be accepted, including azide, nitrite and cyanide. This allows the biocatalytic production of several β -substituted alcohols from epoxides. In these oxirane-ring opening reactions, the halohydrin dehalogenase from Agrobacterium radiobacter displays high enantioselectivity, making it possible to use the enzyme for the preparation of enantiopure building blocks for fine chemicals.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
0098050

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Majerić-Elenkov (autor)


Citiraj ovu publikaciju:

Janssen, Dick; Majerić Elenkov, Maja; Hasnaoui, Ghannia; Hauer, Bernhard; Lutje Spelberg, Jeffrey
Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases // Biochemical Society Transactions, 34 (2006), 2; 291-295 (međunarodna recenzija, pregledni rad, znanstveni)
Janssen, D., Majerić Elenkov, M., Hasnaoui, G., Hauer, B. & Lutje Spelberg, J. (2006) Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases. Biochemical Society Transactions, 34 (2), 291-295.
@article{article, year = {2006}, pages = {291-295}, keywords = {biocatalysis, azide, cyanide, epoxide, halohydrin dehalogenase}, journal = {Biochemical Society Transactions}, volume = {34}, number = {2}, issn = {0300-5127}, title = {Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases}, keyword = {biocatalysis, azide, cyanide, epoxide, halohydrin dehalogenase} }
@article{article, year = {2006}, pages = {291-295}, keywords = {biocatalysis, azide, cyanide, epoxide, halohydrin dehalogenase}, journal = {Biochemical Society Transactions}, volume = {34}, number = {2}, issn = {0300-5127}, title = {Enantioselective formation and ring-opening of epoxides catalyzed by halohydrin dehalogenases}, keyword = {biocatalysis, azide, cyanide, epoxide, halohydrin dehalogenase} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka::


  • Chemical Abstracts





Contrast
Increase Font
Decrease Font
Dyslexic Font