In vitro detection of cellular immunity to melanoma antigens in man by the monocyte spreading inhibition test (CROSBI ID 124575)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Mažuran, Renata ; Mujagić, Hamza ; Malenica, Branko ; Silobrčić, Vlatko
engleski
In vitro detection of cellular immunity to melanoma antigens in man by the monocyte spreading inhibition test
In vitro inhibition of monocyte spreading (a correlate of cellular immunity)was used to detect cell-mediated immune reactions of melanoma patients to specific melanoma antigens. Two soluble preparations of human melanoma antigens (MA-1 and MA-2) and one of a breast carcinoma (BCA) were prepared. The preparations were incubated in vitro with mononuclear cells isolated from the blood of 24 patients with melanoma, sx patients with malignancies other than melanoma and 14 healthy donors. Spreading of monocytes from healthy donors was not inhibited by either MA-1 and MA-2 or BCA. MA-1 and MA-2 significantly inhibited the spreading of monocytes from patients with melanoma, while monocytes from patients with other malignancies were not affected. Spreading of monocytes from patients with melanoma was inhibited by the preparation of BCA. We conclude that inhibition of monocyte spreading can detect, in vitro, a cellular immune reaction to specific melanoma antigens in patients with melanoma.
melanoma ; cellular immunity ; monocyte spreading inhibition
Rad je prezentiran na skupu II European Immunology Meeting, održanom u rujnu 1975.g., Amsterdam, Nizozemska.
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Podaci o izdanju
17 (1)
1976.
14-20
objavljeno
0020-7136
1097-0215
10.1002/ijc.2910170104
Povezanost rada
Temeljne medicinske znanosti, Kliničke medicinske znanosti