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Pregled bibliografske jedinice broj: 253768

Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents


Pawlica, Dariusz; Radić Stojković, Marijana; Sieron, Les1aw; Piantanida, Ivo; Eilmes, Julita
Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents // Tetrahedron, 62 (2006), 39; 9156-9165 doi:10.1016/j.tet.2006.07.045 (međunarodna recenzija, članak, znanstveni)


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Naslov
Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents

Autori
Pawlica, Dariusz ; Radić Stojković, Marijana ; Sieron, Les1aw ; Piantanida, Ivo ; Eilmes, Julita

Izvornik
Tetrahedron (0040-4020) 62 (2006), 39; 9156-9165

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dibenzotetraaza[14]annulenes ; Water-solubilizing groups ; Synthesis ; Crystal structure ; DNA binding ; UV– vis titration ; DNA thermal denaturation.

Sažetak
A series of water-soluble dicationic dibenzotetraaza[14]annulenes have been prepared in order to examine their interactions with nucleic acids. Pendant water-solubilizing N-pyridinium, 4, 40-bipyridinium and N-methyl pyridinium moieties have been attached to the central core via linkers generated by direct N-alkylations and ester creating couplings, respectively. The crystal structures of derivatives equipped with 3-(N-pyridinium-1-yl)propyl and 3-(4, 40-bipyridinium-1-yl)propyl substituents have been determined. Interactions with ct-DNA have been studied and evidenced by means of spectrophotometric titrations with Scatchard analysis and thermal denaturation experiments.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
0098053

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Pawlica, Dariusz; Radić Stojković, Marijana; Sieron, Les1aw; Piantanida, Ivo; Eilmes, Julita
Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents // Tetrahedron, 62 (2006), 39; 9156-9165 doi:10.1016/j.tet.2006.07.045 (međunarodna recenzija, članak, znanstveni)
Pawlica, D., Radić Stojković, M., Sieron, L., Piantanida, I. & Eilmes, J. (2006) Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents. Tetrahedron, 62 (39), 9156-9165 doi:10.1016/j.tet.2006.07.045.
@article{article, year = {2006}, pages = {9156-9165}, DOI = {10.1016/j.tet.2006.07.045}, keywords = {Dibenzotetraaza[14]annulenes, Water-solubilizing groups, Synthesis, Crystal structure, DNA binding, UV– vis titration, DNA thermal denaturation.}, journal = {Tetrahedron}, doi = {10.1016/j.tet.2006.07.045}, volume = {62}, number = {39}, issn = {0040-4020}, title = {Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents}, keyword = {Dibenzotetraaza[14]annulenes, Water-solubilizing groups, Synthesis, Crystal structure, DNA binding, UV– vis titration, DNA thermal denaturation.} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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