Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents (CROSBI ID 124574)
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Podaci o odgovornosti
Pawlica, Dariusz ; Radić Stojković, Marijana ; Sieron, Les1aw ; Piantanida, Ivo ; Eilmes, Julita
engleski
Synthesis, crystal structures and the preliminary evaluation of the new dibenzotetraaza[14]annulene-based DNA/RNA binding agents
A series of water-soluble dicationic dibenzotetraaza[14]annulenes have been prepared in order to examine their interactions with nucleic acids. Pendant water-solubilizing N-pyridinium, 4, 40-bipyridinium and N-methyl pyridinium moieties have been attached to the central core via linkers generated by direct N-alkylations and ester creating couplings, respectively. The crystal structures of derivatives equipped with 3-(N-pyridinium-1-yl)propyl and 3-(4, 40-bipyridinium-1-yl)propyl substituents have been determined. Interactions with ct-DNA have been studied and evidenced by means of spectrophotometric titrations with Scatchard analysis and thermal denaturation experiments.
Dibenzotetraaza[14]annulenes ; Water-solubilizing groups ; Synthesis ; Crystal structure ; DNA binding ; UV– vis titration ; DNA thermal denaturation.
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