engleski

Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne encephalitis

Objectives: The aim of our study was to determine whether cerebrospinal fluid (CSF) of patients with tick-borne encephalitis (TBE) contains CXCL19, CXCL11, p40 subunit of IL-12/IL-23, IL-18 and IL-15. We compared serum and CSF concentrations of CXCL10 and analysed the possible concentration gradient of this chemokine between the periphery and central nervous system. Materials and methods: The study enrolled 19 TBE patients and 10 patients with non-inflammatory neurological diseases. Results: CSF of TBE patients contained CXCL10 (median 217 pg/ml), CXCL11 88.3 pg/ml), p40 subunit of IL-12/IL-23 (38.9 pg/ml), IL18 (30.1 pg/ml) and IL-15 (5.9 pg/ml). CXCL10 in the CSF of TBE patients was higher compared with serum (median 62 pg/ml, p<0.001). Conclusion: CSF of TBE patients contains CXCL10, CXCL11, p40 subunit of IL-12/IL-23, IL-18 and IL-15. Increased CXCL11 concentration in CSF suggests a role for this chemokine in the recruitment of CXCR3-expressing T-cells into the CSF of TBE patients.

tick-borne encephalitis; chemokines; CXCL10; CXCL11

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