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The metabolic fate of 14C-labeled peptidoglycan monomer in mice. Identification of the monomer and the corresponding pentapeptide in urine (CROSBI ID 124451)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Tomašić, Jelka ; Ladešić, Branko ; Valinger, Zdenka ; Hršak, Ivo The metabolic fate of 14C-labeled peptidoglycan monomer in mice. Identification of the monomer and the corresponding pentapeptide in urine // Biochimica et biophysica acta. G, General subjects, 629 (1980), 1; 77-82. doi: 10.1016/0304-4165(80)90266-4

Podaci o odgovornosti

Tomašić, Jelka ; Ladešić, Branko ; Valinger, Zdenka ; Hršak, Ivo

engleski

The metabolic fate of 14C-labeled peptidoglycan monomer in mice. Identification of the monomer and the corresponding pentapeptide in urine

The distribution of radioactive products in mouse urine following i.v. administration of the 14-C-labeled peptidoglycan monomer, GlcNAc-MurNAc-L-Ala-D-isoGln-meso-DAP-D-Ala-D-Ala, was studied. 60-80% of radioactivity was recovered within first 3 h, 4-8% in the next 3h and 2-7% in the following 18 h. The majority of the label was associated with the unchanged peptidoglycan monomer (42-56% of the dose). 14-21% of the label was incorporated into a compound which was isolated and tentatively identified as L-Ala-D-isoGln-mesoDAP-D-Ala-D-Ala. The kinetics of excretion and the distribution of radioactivity did not differ in immunized, when compared to non-immunized, mice.

peptidoglycan monomer ; peptidoglycan metabolism ; pentapeptide ; radioactive peptidoglycan monomer

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Podaci o izdanju

629 (1)

1980.

77-82

objavljeno

0304-4165

10.1016/0304-4165(80)90266-4

Povezanost rada

Kemija, Biologija, Temeljne medicinske znanosti

Poveznice
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