engleski

Electrochemical characterization of simvastatin by abrasive stripping and square-wave voltammetry

The electrochemical characteristic of the lipid- lowering drug simvastatin were investigeted on graphite and mercury electrode. Solid microparticles of simvastatin were mechanically immobilized on the surface graphite electrode and immeresed into aqueous electrolyte. The microparticles were oxidized at 1.1. V in totally irreversible electrode reaction. Simvastatin dissolved in acetronitrile and admixed with 0.1 M Na2B4O7-KH2PO4 aqueous buffered solution pH 7 is strongly adsorbed of surface mercury elecreode. Adsorbed simvastatin was reduced at -1.45 V in the fast and reversible electrode reaction by a chemical reaction.

simvastatin ; statins ; graphite electrode ; mercury electrode ; abrasive stripping voltammetry ; cyclic voltammetry ; square-wave voltammetry

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